Targeted protein degradation improves cognition and reduces

Alzheimer′s brain pathology in mouse models

By Helen FloershMar 3, 2023 09:25am

TPDs are a potential fit for “undruggable” diseases like Alzheimer’s because they can selectively degrade proteins

that are difficult to target with traditional small molecules. (Getty Images)

“Collectively, our findings suggest that TPD technology can target a specific [post-translated modification] to induce selective degradation of neurodegenerative disease-associated proteins

such as [phosphyorlated] p38, demonstrating its potential as a therapeutic modality against [Alzheimer’s disease],” the researchers concluded in their paper.

▶ Read the article : https://www.fiercebiotech.com/research/tpd-alzheimers-disease-targeted-protein-degradation-against-modified-p38-protein-improves

[Attachment] ACS thesis